NAME

       tradis_essentiality  -  bio-tradis: produces calls of gene essentiality using an adaptation of the method
       described in Langridge et al.

SYNOPSIS

       tradis_essentiality data.tab

DESCRIPTION

       Produces calls of gene essentiality using an adaptation of the  method  described  in  Langridge  et  al.
       Genome Research 2009 and Barquist et al.  NAR 2013. A loess curve is fit to the distribution of insertion
       indices, and used to identify the minima between the 'essential' and 'non-essential' distributions. These
       distributions are then used to fit gamma distributions, which are then used to calculate log-odds ratios,
       which  are  used to determine an insertion-index threshold for gene essentiality. Note that this analysis
       requires a saturated mutant library, and is not suitable for the analysis of data sets with low insertion
       density. The script produces a number of diagnostic plots which can be used to verify that this condition
       has been met.

AUTHOR

       This manpage was written by Andreas Tille for the Debian distribution and can be used for any other usage
       of the program.

tradis_essentiality 1.3.1                          March 2017                             TRADIS_ESSENTIALITY(1)